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The Systems-Based Neurotechnology for Emerging Therapies (SUBNETS) program is a multi-institutional collaborative project that seeks to achieve an unprecedented understanding of how brain circuitry goes awry in refractory neuropsychological conditions. Our goal is to identify approaches and develop technology to permanently reverse the disabling brain changes that accompany these disorders.

The project combines expertise in clinical care, dissecting and modeling the neural circuits involved in neuropsychological illnesses, and advanced device development. Advanced methodologies are employed to link neurophysiology with behavioral symptoms to guide therapeutic stimulation. Together, we work towards developing the next generation of closed-loop neural stimulation devices and applications which will provide investigators and clinicians increased accessibility to monitor, record, and stimulate target brain regions. Read more about SUBNETS here.


SUBNETS is a DARPA-funded program.



Edward Chang, MD (Principal Investigator, UCSF)

Heather Dawes, PhD (Co-director, Program Manager, UCSF)


Mesocorticolimbic Circuit Dissection / Human Intracranial Recordings


Chang Lab:

Maryam Bijanzadeh, PhD (Post Doc, UCSF)

A. Moses Lee, MD PhD (Resident, Psychiatry, UCSF)

Kristin Sellers, PhD (Post Doc, UCSF)

Ankit Khambhati, PhD (Post Doc, UCSF)


Anthony Fong, BS (UCSF)

Felicia Kuo, BS (UCSF)

Alia Shafi, BS (UCSF)



Cora de Hemptinne, PhD (Assoc Researcher, Neurological Surgery, UCSF)

Howard Fields, MD PhD (Prof, Neurology, UCSF)

Andrew Krystal, MD (Prof, Psychiatry, UCSF)

Vikram Rao, MD PhD (Asst Prof, Neurology, UCSF)

Katherine Scangos, MD PhD (Clinical Fellow, Psychiatry, UCSF)

Maryam Shanechi, PhD (Asst Prof, Electrical Engineering, USC)

Prasad Shirvalkar, MD PhD (Asst Prof, Anesthesia, UCSF)

Vikaas Sohal, MD PhD (Asst Prof, Psychiatry, UCSF)

Philip Starr, MD (Prof, Neurological Surgery, UCSF)


Neurotechnology Development

Dejan Markovic, PhD (Prof, Electrical and Computer Engineering, UCLA)

Razi Haque, PhD (LLNL)

Tim Denison, PhD (Vice President of Research and Core Technology, Medtronic)

Michael Merzenich, PhD (Posit Science)

 Mor Nahum, PhD (Posit Science)

Darko Todorovic, PhD (Head of R&D, HTEC)

Tom VanVleet, PhD (Posit Science)

Dennis Zottola (Director Systems and Software, Boston Scientific)



Jose Carmena, PhD (Prof, Electrical Engineering and Neuroscience, UC Berkeley)

Bijan Pesaran, PhD (Assoc Prof, Neural Science, NYU)